Abstract
Five 8,17-epoxybriaranes, including three new compounds-briarenols I-K (1-3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.
Keywords:
Briareum excavatum; COX-2; anti-inflammatory; briarane; briarenol; iNOS.
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cyclooxygenase 2 / metabolism*
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Down-Regulation
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Gene Expression Regulation, Enzymologic / drug effects
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Mice
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Molecular Structure
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Nitric Oxide Synthase Type II / metabolism*
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RAW 264.7 Cells
Substances
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Anti-Inflammatory Agents
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Diterpenes
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briaexcavatin
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse
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Ptgs2 protein, mouse
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Cyclooxygenase 2