Briarenols I-K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae)

Molecules. 2020 Mar 19;25(6):1405. doi: 10.3390/molecules25061405.

Abstract

Five 8,17-epoxybriaranes, including three new compounds-briarenols I-K (1-3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1-3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

Keywords: Briareum excavatum; COX-2; anti-inflammatory; briarane; briarenol; iNOS.

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cyclooxygenase 2 / metabolism*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Down-Regulation
  • Gene Expression Regulation, Enzymologic / drug effects
  • Mice
  • Molecular Structure
  • Nitric Oxide Synthase Type II / metabolism*
  • RAW 264.7 Cells

Substances

  • Anti-Inflammatory Agents
  • Diterpenes
  • briaexcavatin
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse
  • Ptgs2 protein, mouse
  • Cyclooxygenase 2