Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Chao-Hsien Chen; Ching-Liang Hsieh

doi:10.3390/antiox9030248

Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Antioxidants (Basel). 2020 Mar 19;9(3):248. doi: 10.3390/antiox9030248.

Authors

Chao-Hsien Chen¹, Ching-Liang Hsieh^{1

2

3}

Affiliations

¹ Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
² Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan.
³ Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

Abstract

In this article, we review how acupuncture regulates oxidative stress to prevent ischemia-reperfusion injury. We electronically searched databases, including PubMed, Clinical Key and the Cochrane Library, from their inception to November 2019 by using the following medical subject headings and keywords: acupuncture, ischemia-reperfusion injury, oxidative stress, reactive oxygen species, and antioxidants. We concluded that acupuncture is effective in treating oxidation after ischemia-reperfusion injury. In addition to increasing the activity of antioxidant enzymes and downregulating the generation of reactive oxygen species (ROS), acupuncture also repairs the DNA, lipids, and proteins attacked by ROS and mediates downstream of the ROS pathway to apoptosis.

Keywords: acupuncture; ischemia-reperfusion injury; oxygen free radical.

Publication types

Review