Laser-triggered drug release from polymeric 3-D micro-structured films via optical fibers

Maxim A Kurochkin; Olga A Sindeeva; Ekaterina P Brodovskaya; Meiyu Gai; Johannes Frueh; Lei Su; Andrei Sapelkin; Valery V Tuchin; Gleb B Sukhorukov

doi:10.1016/j.msec.2020.110664

Laser-triggered drug release from polymeric 3-D micro-structured films via optical fibers

Mater Sci Eng C Mater Biol Appl. 2020 May:110:110664. doi: 10.1016/j.msec.2020.110664. Epub 2020 Jan 15.

Authors

Maxim A Kurochkin¹, Olga A Sindeeva², Ekaterina P Brodovskaya³, Meiyu Gai⁴, Johannes Frueh⁵, Lei Su⁶, Andrei Sapelkin⁷, Valery V Tuchin⁸, Gleb B Sukhorukov⁹

Affiliations

¹ Skolkovo Institute of Science and Technology, 3 Nobelya Str., Moscow 143025, Russia; Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education Micro/Nanotechnology Research Centre, Harbin Institute of Technology, 2 Yikuang Street B1, 150080 Harbin, China. Electronic address: M.Kurochkin@skoltech.ru.
² Remote Controlled Theranostic Systems Lab, Department of Nanotechnology, Educational and Research Institute of Nanostructures and Biosystems, Saratov State University, Saratov 410012, Russia; Surface Engineering Lab, Innovative Engineering Technologies Institute, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow 117198, Russia.
³ National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., Saransk 430005, Republic of Mordovia, Russia.
⁴ School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom; Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany.
⁵ Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education Micro/Nanotechnology Research Centre, Harbin Institute of Technology, 2 Yikuang Street B1, 150080 Harbin, China; Institute of Environmental Engineering, Eidgenoessische Technische Hochschule Zurich, Stefano-Franscini-Platz 3, 8093 Zurich, Switzerland.
⁶ School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom.
⁷ School of Physics and Astronomy, Queen Mary University of London, London E1 4NS, United Kingdom.
⁸ Interdisciplinary Laboratory of Biophotonics, Tomsk State University, 36 Lenin's av., Tomsk 634050, Russia; Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control of the Russian Academy of Science, 24 Rabochaya str., Saratov 410028, Russia; Research-Educational Institute of Optics and Biophotonics, Saratov State University, 83 Astrakhanskaya street, Saratov 410012, Russia.
⁹ Skolkovo Institute of Science and Technology, 3 Nobelya Str., Moscow 143025, Russia; School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, United Kingdom; Surface Engineering Lab, Innovative Engineering Technologies Institute, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow 117198, Russia; I. M. Sechenov First Moscow State Medical University, Moscow 119991, Russia.

PMID: 32204092
DOI: 10.1016/j.msec.2020.110664

Abstract

Photosensitive polymeric three-dimensional microstructured film (PTMF) is a new type of patterned polymeric films functionalized with an array of sealed hollow 3D containers. The microstructured system with enclosed chemicals provides a tool for the even distribution of biologically active substances on a given surface that can be deposited on medical implants or used as a cells substrate. In this work, we proposed a way for photothermally activating and releasing encapsulated substances at picogram amounts from the PTMF surface in different environments using laser radiation delivered with a multimode optical fiber. The photosensitive PTMFs were prepared by the layer-by-layer (LbL) assembly from alternatively charged polyelectrolytes followed by covering with a layer of hydrophobic polylactic acid (PLA) and a layer of gold nanoparticles (AuNPs). Moreover, the typical photothermal cargo release amounts were determined on the surface of the PTMF for a range of laser powers delivered to films placed in the air, deionized (DI) water, and 1% agarose gel. The agarose gel was used as a soft tissue model for developing a technique for the laser activation of PTMFs deep in tissues using optical waveguides. The number of PTMF chambers activated by a near-infrared (NIR) laser beam was evaluated as the function of optical parameters.

Keywords: Chamber array; Controlled drug delivery; Infrared laser; Microstructured film; Optical fiber; Polyelectrolyte multilayer.

MeSH terms

Drug Liberation*
Infrared Rays
Lasers*
Optical Fibers*
Polyelectrolytes / chemistry
Polymers / chemistry*
Static Electricity

Substances

Polyelectrolytes
Polymers