Features of electron beam deposition of polymer coatings with the prolonged release of the drug component

Beibei Li; Yiming Liu; A V Rogachev; V A Yarmolenko; A A Rogachev; A E Pyzh; Xiaohong Jiang; M A Yarmolenko

doi:10.1016/j.msec.2020.110730

Features of electron beam deposition of polymer coatings with the prolonged release of the drug component

Mater Sci Eng C Mater Biol Appl. 2020 May:110:110730. doi: 10.1016/j.msec.2020.110730. Epub 2020 Feb 4.

Authors

Beibei Li¹, Yiming Liu¹, A V Rogachev², V A Yarmolenko³, A A Rogachev², A E Pyzh⁴, Xiaohong Jiang⁵, M A Yarmolenko²

Affiliations

¹ International Chinese-Belorussian Scientific laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei street, Nanjing 210094, China.
² International Chinese-Belorussian Scientific laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei street, Nanjing 210094, China; Francisk Skorina Gomel State University, 104, Sovetskaya street, Gomel 246019, Belarus.
³ Gomel State Medical University, 5, Lange street, Gomel 246000, Belarus.
⁴ Institute of physiology National Academy of Sciences of Belarus, 28, Academicheskaya street, Minsk 220072, Belarus.
⁵ International Chinese-Belorussian Scientific laboratory on Vacuum-Plasma Technology, Nanjing University of Science and Technology, 200, Xiaolingwei street, Nanjing 210094, China. Electronic address: jiangxh24@njust.edu.cn.

PMID: 32204041
DOI: 10.1016/j.msec.2020.110730

Abstract

The first part of the paper provides a comprehensive analysis of the features of electron beam formation of polymer coatings with the prolonged release of the drug compound using ciprofloxacin and clotrimazole as an example. The influence features of the low-energy electron beam on the molecular structure of medicinal chemical preparations have been established. The impossibility of producing the coatings based on medicinal compounds with a complex molecular structure (vancomycin, micafungin, etc.) by a low-energy electron beam has been justified. The second part of the paper introduces a fundamentally new vacuum method for the formation of the composite coatings based on antibiotics and antifungal drugs, accompanied by the prolonged release of the drug component. This method allows the formation of composite coatings based on medicinal compounds with a complex molecular structure. It is effective for modifying implants to prevent the risk of implant-associated infectious complications which are the result of the occurrence of mixed biofilms. The method can be used to form composite layers based on topical antitumor drugs for cancer control.

Keywords: Ciprofloxacin; Clotrimazole; Electron-beam deposition; Micafungin; Polymer coatings; Vancomycin.

MeSH terms

Anti-Bacterial Agents* / chemistry
Anti-Bacterial Agents* / pharmacology
Antifungal Agents* / chemistry
Antifungal Agents* / pharmacology
Coated Materials, Biocompatible* / chemistry
Coated Materials, Biocompatible* / pharmacology
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / pharmacology
Electrons*
Implants, Experimental

Substances

Anti-Bacterial Agents
Antifungal Agents
Coated Materials, Biocompatible
Delayed-Action Preparations