Advanced case of PKDL due to delayed treatment: A rare case report

Roshan Kamal Topno; Vidya Nand Rabi Das; Maneesh Kumar; Major Madhukar; Krishna Pandey; Neena Verma; Kanhaiya Agrawal; Chandra Shekhar Lal; Niyamat Ali Siddiqui; Sanjiva Bimal; Pradeep Das

doi:10.1371/journal.pntd.0008052

Advanced case of PKDL due to delayed treatment: A rare case report

PLoS Negl Trop Dis. 2020 Mar 23;14(3):e0008052. doi: 10.1371/journal.pntd.0008052. eCollection 2020 Mar.

Authors

Affiliations

¹ Department of Epidemiology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
² Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
³ Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
⁴ Department of Pathology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
⁵ Department of Clinical Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
⁶ Department of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
⁷ Department of Immunology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.
⁸ Department of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.

Abstract

Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Leishmania donovani has been reported and is one of the major concerns in the treatment of PKDL. Here, we report a highly ulcerated PKDL case that was successfully cured after miltefosine treatment.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antiprotozoal Agents / therapeutic use
Humans
India
Leishmania donovani / isolation & purification
Leishmaniasis, Cutaneous / diagnosis*
Leishmaniasis, Cutaneous / drug therapy*
Leishmaniasis, Cutaneous / etiology*
Leishmaniasis, Cutaneous / parasitology
Leishmaniasis, Visceral / complications*
Leishmaniasis, Visceral / diagnosis
Leishmaniasis, Visceral / drug therapy*
Leishmaniasis, Visceral / parasitology
Male
Middle Aged
Phosphorylcholine / analogs & derivatives
Phosphorylcholine / therapeutic use
Skin / diagnostic imaging
Skin / pathology

Substances

Antiprotozoal Agents
Phosphorylcholine
miltefosine

Grants and funding

The study is funded by Indian Council of Medical Research, New Delhi. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.