A cyclic peptide and two pairs of norlignan lignanoside epimers from Selaginella pulvinata

Fitoterapia. 2020 Jun:143:104562. doi: 10.1016/j.fitote.2020.104562. Epub 2020 Mar 18.

Abstract

A new cyclopeptide, pulvpeptin A (1), two pairs of norlignan lignanosides, tamariscinosides G and H (2, 3), together with five known compounds (4-8) were isolated from Selaginella pulvinata. The structures were elucidated by spectroscopic data and chemical degradation. The activity of tamariscinoside G (2) was evaluated by stimulating glucose uptake in 3T3-L1 adipocytes. The results showed 1.49-fold increase in glucose uptake in 3T3-L1 cells relative to basal.

Keywords: Cyclic peptide; Norlignan lignanoside; Selaginella pulvinata; Selaginellaceae.

MeSH terms

  • 3T3-L1 Cells
  • Animals
  • China
  • Glucose / metabolism
  • Lignans / isolation & purification
  • Lignans / pharmacology*
  • Mice
  • Molecular Structure
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / pharmacology*
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Selaginellaceae / chemistry*

Substances

  • Lignans
  • Peptides, Cyclic
  • Phytochemicals
  • Glucose