Putting the brakes on a myosin motor

Casey Eddington; Margaret A Titus

doi:10.1074/jbc.H120.013153

Putting the brakes on a myosin motor

J Biol Chem. 2020 Mar 20;295(12):3757-3758. doi: 10.1074/jbc.H120.013153.

Authors

Casey Eddington¹, Margaret A Titus²

Affiliations

¹ Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455.
² Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455 titus004@umn.edu.

Abstract

Insulin-stimulated trafficking of GLUT4 requires the myosin motor Myo1C and signaling adaptor 14-3-3β. Originally, it was thought that 14-3-3β promotes GLUT4 transport by binding the Myo1C lever arm and activating the Myo1C motor. New work by Ji and Ostap using in vitro assays reveals that 14-3-3β binding actually inhibits Myo1C motility, prompting reconsideration of the functional relationship between 14-3-3β and Myo1C and the regulatory potential of atypical light chains.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Insulin
Myosin Type I* / metabolism
Myosins* / genetics
Myosins* / metabolism
Phosphorylation
Protein Transport

Substances

Insulin
Myosin Type I
Myosins

Grants and funding

R01 GM122917/GM/NIGMS NIH HHS/United States