Prognostic significance of poorly cohesive gastric carcinoma in Tunisian patients

Raja Jouini; Fatma Khanchel; Meriam Sabbah; Imen Helal; Abdessalem Gharsallah; Marwa Ferchichi; Dhafer Hadded; Haithem Zaafouri; Ehsen Ben Brahim; Anis Ben Maamer; Aschraf Chadli Debbiche

doi:10.1016/j.heliyon.2020.e03460

Prognostic significance of poorly cohesive gastric carcinoma in Tunisian patients

Heliyon. 2020 Mar 14;6(3):e03460. doi: 10.1016/j.heliyon.2020.e03460. eCollection 2020 Mar.

Authors

Raja Jouini^{1

2}, Fatma Khanchel^{1

2}, Meriam Sabbah^{3

2}, Imen Helal^{1

2}, Abdessalem Gharsallah², Marwa Ferchichi^{1

4}, Dhafer Hadded^{2

5}, Haithem Zaafouri^{2

5}, Ehsen Ben Brahim^{1

2}, Anis Ben Maamer^{2

5}, Aschraf Chadli Debbiche^{1

2}

Affiliations

¹ Department of Pathology, Habib Thameur Hospital, Tunis, Tunisia.
² Faculty of Medicine of Tunis, Tunis El Manar University, Tunisia.
³ Department of Gastroenterology, Habib Thameur Hospital, Tunis, Tunisia.
⁴ Faculty of Sciences of Tunis, Tunis El Manar University, Tunisia.
⁵ Department of Surgery, Habib Thameur Hospital, Tunisia.

Abstract

Background: While the incidence of gastric cancer has decreased worldwide in recent decades, the incidence of poorly cohesive carcinoma (PCC) is rising. The prognostic significance of gastric PCC remains a subject of debate.

Objective: To analyze the prognosis of gastric PCC in a Tunisian cohort.

Methods: A total of 122 gastric adenocarcinoma patients who underwent curative gastrectomy from 2001 to 2014 at Habib Thameur hospital in Tunis, Tunisia were included. The clinicopathological parameters and prognosis of PCC were analyzed in comparison with non PCC (NPCC).

Results: Sixty one patients (50%) presented PCC. Patients were younger in PCC group (p = 0,001). There was no difference in sex distribution between the two groups. PCC was more likely to be stage T4 (55.7% vs 34.4%; p = 0.033), N3 (67.8% vs 30%; p < 0.001) and have a higher metastatic lymph node ratio (p < 0.001). Hepatic metastases were more frequent in NPCC group (p = 0.031) whereas peritoneal carcinomatosis was more common in PCC group (p = 0.004). Perineural invasion was more frequent in PCC group (p = 0.001). Resection margins were more often positive in PCC group (31.1% vs 9.8%; p = 0.004). There was no difference in recurrence rate between the 2 groups (p = 0.348). The 5-year survival was similar in the NPCC and PCC (respectively 43% vs 23 %; p = 0.247). Survival rates were also comparable in early stage (100% vs 80% respectively for PCC and NPCC; p = 0.527) as well as for advanced stage (16% vs 35% respectively for PCC and NPCC; p = 0.538). PCC was not a prognostic factor for survival. Interestingly, advanced age, adjacent structures invasion, positive resection margins were specific prognostic factors for PCC.

Conclusion: In our study PCC was not a prognostic factor for survival. Advanced age, adjacent structures invasion and positive resection margins were specific prognostic features for this histological subtype.

Keywords: Abdominal surgery; Biological sciences; Cancer surgery; Gastric cancer; Health sciences; Pathology; Poorly cohesive carcinoma; Prognosis; Survival.