An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4+ T cells

Manickam Ashokkumar; Aanand Sonawane; Balakumaran Sathiyamani; Bennett Henzeler Esakialraj L; Luke Elizabeth Hanna

doi:10.1016/j.dib.2020.105365

An in vitro dataset on infectious potential of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses generated from Interferon alpha-treated primary CD4⁺ T cells

Data Brief. 2020 Feb 29:29:105365. doi: 10.1016/j.dib.2020.105365. eCollection 2020 Apr.

Authors

Manickam Ashokkumar^{1

2}, Aanand Sonawane^{1

2}, Balakumaran Sathiyamani¹, Bennett Henzeler Esakialraj L¹, Luke Elizabeth Hanna¹

Affiliations

¹ Department of HIV/AIDS, National Institute for Research in Tuberculosis, Chennai, India.
² University of Madras, Chennai, India.

Abstract

This data article describes the infectivity of transmitted/founder (TF) and non-TF (NT) HIV-1 viruses derived from primary CD4⁺ T cells treated with or without IFN-α, over a period of 12 days. TF and NT viruses described in this article were derived from the same individual (one of each from 8 infants who acquired HIV infection through mother-to-child transmission (MTCT). IFN-α resistance to both TF and NT viruses was studied by infecting TZM-bl cells and measuring luciferase expression (expressed as relative light units, RLU). Measurement of luciferase expression is extremely sensitive and allows quantification of even small changes in gene expression at the transcriptional level.

Keywords: Human immunodeficiency virus; Interferon alpha resistance; Mother-to-Child transmission; Transmitted founder viruses.