Single-Cell Analysis of Foot-and-Mouth Disease Virus

Hailong Wang; Xiu Xin; Congyi Zheng; Chao Shen

doi:10.3389/fmicb.2020.00361

Single-Cell Analysis of Foot-and-Mouth Disease Virus

Front Microbiol. 2020 Mar 5:11:361. doi: 10.3389/fmicb.2020.00361. eCollection 2020.

Authors

Hailong Wang^{1

2}, Xiu Xin³, Congyi Zheng^{1

4}, Chao Shen^{1

4}

Affiliations

¹ State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.
² Center for Experimental Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China.
³ Institute of Pathogenic Microorganism and College of Bioscience and Engineering, Jiangxi Agricultural University, Nanchang, China.
⁴ China Center for Type Culture Collection, Wuhan University, Wuhan, China.

Abstract

With the rapid development of single-cell technologies, the mechanisms underlying viral infections and the interactions between hosts and viruses are starting to be explored at the single-cell level. The foot-and-mouth-disease (FMD) virus (FMDV) causes an acute and persistent infection that can result in the break-out of FMD, which can have serious effects on animal husbandry. Single-cell techniques have emerged as powerful approaches to analyze virus infection at the resolution of individual cells. In this review, the existing single-cell studies examining FMDV will be systematically summarized, and the central themes of these studies will be presented.

Keywords: FMDV; heterogeneity; isolation; persistent infection; single-cell.

Publication types

Review