New metabolites from the marine-derived bacterium Pseudomonas sp. ZZ820R

Fitoterapia. 2020 Jun:143:104555. doi: 10.1016/j.fitote.2020.104555. Epub 2020 Mar 17.

Abstract

Six previously undescribed compounds, named monaxanthones A and B, monaphenol A, monathioamide A, monaprenylindole A, and monavalerolactone A, were isolated from the culture of a marine-sourced bacterium Pseudomonas sp. ZZ820R in rice medium. Their structures were elucidated based on the HRESIMS data, NMR and MS-MS spectroscopic analyses, optical rotation and ECD calculations. Monathioamide A is an unprecedented sulfur-contained compound and monavalerolactone A represents the first example of this type of natural products. Monaprenylindole A showed antibacterial activity against methicillin-resistant Staphylococcus aureus.

Keywords: Antibacterial activity; Marine bacterium; New metabolites; Pseudomonas sp. ZZ820R; Structure elucidation.

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Aquatic Organisms / chemistry
  • Cell Line, Tumor
  • China
  • Escherichia coli / drug effects
  • Humans
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Pseudomonas / chemistry*
  • Soil Microbiology
  • Tandem Mass Spectrometry
  • Thioamides / isolation & purification
  • Thioamides / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Lactones
  • Thioamides