Prognostication of neurological outcome after cardiac arrest using wavelet phase coherence analysis of cerebral oxygen

Abstract

Background: The prognosis for cardiac arrest (CA) is associated with the degree of cerebral ischemia. We investigated the relationship between the wavelet coherence of cerebral oxyhemoglobin (HbO₂) among different channels and outcomes after CA. Moreover, we aimed to develop a prognostication method after CA.

Methods: Eighty-three post-resuscitation patients were included. The HbO₂ data were collected during the post-resuscitation period (median day, 1) using functional near-infrared spectroscopy. The coherence between sections of prefrontal HbO₂ oscillations in five frequency intervals (I, 0.6-2 Hz; II, 0.15-0.6 Hz; III, 0.05-0.15 Hz; IV, 0.02-0.05 Hz; and V, 0.0095-0.02 Hz) were analyzed. We evaluated the outcomes using cerebral performance category (CPC) scores (good outcome, CPC ≤ 2 and poor outcome, CPC ≥ 3) at 3 months after CA. Additionally, the predictive method was developed using the biomarker and coherence value after CA.

Results: Among the included patients, 19 patients (22.9%) had a good outcome. Poor outcome group had significantly lower phase coherence in the myogenic frequency interval III compared to good outcome group (0.36 ± 0.14 vs. 0.54 ± 0.18, P < 0.001). The predictive method using neuron-specific enolase (NSE) and interval III value demonstrated good discrimination (area under the curve 0.919; 95% confidence interval, 0.850-0.989).

Conclusions: The predictive method using NSE and phase coherence of HbO₂ in the interval III from the vascular smooth muscle cells could be a useful tool for prognosticating after CA. This suggests that evaluating cerebral ischemia using phase coherence of HbO₂ might be a helpful outcome predictor following CA.

Keywords: Cardiac arrest; Cerebral oxyhemoglobin; Functional near-infrared spectroscopy; Hypoxic-ischemic brain injury; Prognosis; Wavelet phase coherence.