Dietary SCFAs Immunotherapy: Reshaping the Gut Microbiota in Diabetes

Adv Exp Med Biol. 2021:1307:499-519. doi: 10.1007/5584_2020_515.

Abstract

Diet-microbiota related inflammatory conditions such as obesity, autoimmune type 1 diabetes (T1D), type 2 diabetes (T2D), cardiovascular disease (CVD) and gut infections have become a stigma in Western societies and developing nations. This book chapter examines the most relevant pre-clinical and clinical studies about diet-gut microbiota approaches as an alternative therapy for diabetes. We also discuss what we and others have extensively investigated- the power of dietary short-chain fatty acids (SCFAs) technology that naturally targets the gut microbiota as an alternative method to prevent and treat diabetes and its related complications.

Keywords: Clinical trials; Diet; Microbiota; SCFAs; T1D; T2D.

MeSH terms

  • Diabetes Mellitus, Type 2 / diet therapy*
  • Diet
  • Fatty Acids, Volatile / administration & dosage*
  • Gastrointestinal Microbiome*
  • Humans
  • Immunotherapy*

Substances

  • Fatty Acids, Volatile