p62 as a therapeutic target for tumor

Eur J Med Chem. 2020 May 1:193:112231. doi: 10.1016/j.ejmech.2020.112231. Epub 2020 Mar 17.

Abstract

p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural domains of p62, reported bioactive molecules targeting p62, and the relationship between p62 and tumorigenesis.

Keywords: Autophagy; NF-κB; Nrf2; Tumor; mTORC1; p62/SQSTM1.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Humans
  • Molecular Structure
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Sequestosome-1 Protein / antagonists & inhibitors*
  • Sequestosome-1 Protein / metabolism

Substances

  • Antineoplastic Agents
  • SQSTM1 protein, human
  • Sequestosome-1 Protein