SJS/TEN 2019: From science to translation

Wan-Chun Chang; Riichiro Abe; Paul Anderson; Wanpen Anderson; Michael R Ardern-Jones; Thomas M Beachkofsky; Teresa Bellón; Agnieszka K Biala; Charles Bouchard; Gianpiero L Cavalleri; Nicole Chapman; James Chodosh; Hyon K Choi; Ricardo R Cibotti; Sherrie J Divito; Karen Dewar; Ulrike Dehaeck; Mahyar Etminan; Diane Forbes; Esther Fuchs; Jennifer L Goldman; James H Holmes 4th; Elyse A Hope; Shuen-Iu Hung; Chia-Ling Hsieh; Alfonso Iovieno; Julienne Jagdeo; Mee Kum Kim; David M Koelle; Mario E Lacouture; Sophie Le Pallec; Rannakoe J Lehloenya; Robyn Lim; Angie Lowe; Jean McCawley; Julie McCawley; Robert G Micheletti; Maja Mockenhaupt; Katie Niemeyer; Michael A Norcross; Douglas Oboh; Cristina Olteanu; Helena B Pasieka; Jonathan Peter; Munir Pirmohamed; Michael Rieder; Hajirah N Saeed; Neil H Shear; Christine Shieh; Sabine Straus; Chonlaphat Sukasem; Cynthia Sung; Jason A Trubiano; Sheng-Ying Tsou; Mayumi Ueta; Simona Volpi; Chen Wan; Hongsheng Wang; Zhao-Qing Wang; Jessica Weintraub; Cindy Whale; Lisa M Wheatley; Sonia Whyte-Croasdaile; Kristina B Williams; Galen Wright; Sonia N Yeung; Li Zhou; Wen-Hung Chung; Elizabeth J Phillips; Bruce C Carleton

doi:10.1016/j.jdermsci.2020.02.003

SJS/TEN 2019: From science to translation

J Dermatol Sci. 2020 Apr;98(1):2-12. doi: 10.1016/j.jdermsci.2020.02.003. Epub 2020 Mar 7.

Authors

Wan-Chun Chang¹, Riichiro Abe², Paul Anderson³, Wanpen Anderson³, Michael R Ardern-Jones⁴, Thomas M Beachkofsky⁵, Teresa Bellón⁶, Agnieszka K Biala¹, Charles Bouchard⁷, Gianpiero L Cavalleri⁸, Nicole Chapman⁹, James Chodosh¹⁰, Hyon K Choi¹¹, Ricardo R Cibotti¹², Sherrie J Divito¹³, Karen Dewar¹⁴, Ulrike Dehaeck¹⁵, Mahyar Etminan¹⁶, Diane Forbes¹⁷, Esther Fuchs¹⁸, Jennifer L Goldman¹⁹, James H Holmes 4th²⁰, Elyse A Hope²¹, Shuen-Iu Hung²², Chia-Ling Hsieh²³, Alfonso Iovieno²⁴, Julienne Jagdeo²¹, Mee Kum Kim²⁵, David M Koelle²⁶, Mario E Lacouture²⁷, Sophie Le Pallec²⁸, Rannakoe J Lehloenya²⁹, Robyn Lim³⁰, Angie Lowe³¹, Jean McCawley³, Julie McCawley³, Robert G Micheletti³², Maja Mockenhaupt³³, Katie Niemeyer³⁴, Michael A Norcross³⁵, Douglas Oboh³, Cristina Olteanu³⁶, Helena B Pasieka³⁷, Jonathan Peter³⁸, Munir Pirmohamed³⁹, Michael Rieder⁴⁰, Hajirah N Saeed¹⁰, Neil H Shear⁴¹, Christine Shieh⁴², Sabine Straus⁴³, Chonlaphat Sukasem⁴⁴, Cynthia Sung⁴⁵, Jason A Trubiano⁴⁶, Sheng-Ying Tsou²³, Mayumi Ueta⁴⁷, Simona Volpi⁴⁸, Chen Wan²¹, Hongsheng Wang⁴⁹, Zhao-Qing Wang²³, Jessica Weintraub⁵⁰, Cindy Whale⁵¹, Lisa M Wheatley⁵², Sonia Whyte-Croasdaile⁵¹, Kristina B Williams⁵³, Galen Wright¹, Sonia N Yeung²⁴, Li Zhou⁵⁴, Wen-Hung Chung⁵⁵, Elizabeth J Phillips⁵⁶, Bruce C Carleton⁵⁷

Affiliations

¹ Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
² Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
³ Stevens-Johnson Syndrome Foundation, Westminster, CO, USA.
⁴ Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
⁵ Wilford Hall Ambulatory Surgical Center, Lackland Air Force Base, TX, USA.
⁶ Drug Hypersensitivity Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
⁷ Loyola University Medical Center, Chicago, IL, USA.
⁸ School of Pharmacy and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; FutureNeuro SFI Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
⁹ SJS Awareness Oregon, Klamath Falls, OR, USA.
¹⁰ Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
¹¹ Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, USA.
¹² National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
¹³ Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
¹⁴ Genome Canada, Ottawa, ON, Canada.
¹⁵ Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
¹⁶ Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
¹⁷ Canadian Institutes of Health Research, Ottawa, ON, Canada.
¹⁸ Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
¹⁹ Children's Mercy Hospital Kansas City, Kansas City, MO, USA.
²⁰ Wake Forest University School of Medicine, WFBMC Burn Center, Winston-Salem, NC, USA.
²¹ Genome British Columbia, Vancouver, BC, Canada.
²² Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
²³ Eden Social Welfare Foundation, Taipei, Taiwan.
²⁴ Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver General Hospital Eye Care Center, Vancouver, BC, Canada.
²⁵ Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.
²⁶ Department of Medicine, University of Washington, Seattle, WA, USA.
²⁷ Memorial Sloan Kettering Cancer Center, New York, NY, USA.
²⁸ Association des malades des syndromes de Lyell et de Stevens-Johnson (Amalyste), Paris, France.
²⁹ Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
³⁰ Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.
³¹ SJS/TEN International Awareness (STIA), Lucky Lake, SK, Canada.
³² Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³³ Dokumentationszentrum schwerer Hautreaktionen (dZh), Department of Dermatology, Medical Center and Medical Faculty, University of Freiburg, Freiburg, Germany.
³⁴ SJ Syndrome of Texas, Austin, TX, USA.
³⁵ Laboratory of Immunology, Division of Biotechnology Review and Research III (DBRR III), Office of Biotechnology Products (OBP), Office of Pharmaceutical Quality (OPQ), Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, USA.
³⁶ Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
³⁷ Department of Dermatology, MedStar Washington Hospital Center, Washington, DC, USA.
³⁸ Division of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
³⁹ Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
⁴⁰ Department of Paediatrics, Children's Hospital/London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
⁴¹ Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
⁴² Department of Ophthalmology, Vanderbilt Eye Institute, Nashville, TN, USA.
⁴³ Dutch Medicines Evaluation Board, Pharmacovigilance Risk Assessment Committee, European Medicines Agency, Utrecht, the Netherlands.
⁴⁴ Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
⁴⁵ Health Products Regulation Group, Health Sciences Authority Singapore, Duke-NUS Medical School, Singapore.
⁴⁶ Department of Infectious Diseases, Austin Health, Heidelberg, Germany; Department of Medicine, University of Melbourne, Victoria, Australia.
⁴⁷ Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
⁴⁸ National Human Genome Research Institute, NIH, Bethesda, MD, USA.
⁴⁹ Institute of Dermatology, Chinese Academy of Medical Sciences, National Center for STD and Leprosy Control, China CDC, Nanjing, China.
⁵⁰ Division of Pharmacovigilance I, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, USA.
⁵¹ SJS Canada, Brantford, ON, Canada.
⁵² National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
⁵³ Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁵⁴ Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵⁵ Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, Keelung, Taoyuan, Taiwan; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address: chung1@cgmh.org.tw.
⁵⁶ Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: elizabeth.j.phillips@vumc.org.
⁵⁷ Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada. Electronic address: bcarleton@popi.ubc.ca.

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs.

Keywords: Human leukocyte antigen (HLA); Pharmacogenomics; Pharmacovigilance; Severe cutaneous adverse reaction (SCAR); Stevens-Johnson syndrome (SJS); Toxic epidermal necrolysis (TEN).

MeSH terms

Congresses as Topic
Global Burden of Disease
Global Health
Health Services Needs and Demand / organization & administration*
Humans
International Cooperation
Patient Care Team / organization & administration*
Pharmacogenetics / organization & administration
Registries / statistics & numerical data
Stevens-Johnson Syndrome / epidemiology
Stevens-Johnson Syndrome / etiology
Stevens-Johnson Syndrome / therapy*
Translational Research, Biomedical / organization & administration

Abstract

MeSH terms

Grants and funding