Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer

Biochem Biophys Res Commun. 2020 May 21;526(1):14-20. doi: 10.1016/j.bbrc.2020.03.024. Epub 2020 Mar 17.

Abstract

Circular RNAs (circRNAs) are a novel class of non-coding RNAs which play important roles in human diseases and tumor progression. However, the function of circRNAs in ovarian cancer remains to be uncovered. Here we found a large amount of circRNAs that are differentially expressed in ovarian cancer tissues compared with normal ovarian tissues. We further identified one circRNA derived from the LPAR3 gene and termed Circ0004390, which was frequently upregulated in ovarian cancer tissues. The knockdown of Circ0004390 can significantly reduce the proliferation of ovarian cancer cells. We further demonstrated that Circ0004390 may promote cell proliferation by acting as a sponge for the miR-198 family to regulated the MET expression in ovarian cancer cells. The level of Circ0004390 was closely related with overall survival of ovarian cancer patients. Our findings suggested that Circ0004390 regulated ovarian cancer proliferation by miR-198/MET axis, which might provide a potential target for the treatment of ovarian cancer.

Keywords: MET; Ovarian cancer; circ_0004390; miR-198.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • HEK293 Cells
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology*
  • Proto-Oncogene Proteins c-met / metabolism
  • RNA, Circular / genetics
  • RNA, Circular / metabolism*

Substances

  • MIRN198 microRNA, human
  • MicroRNAs
  • RNA, Circular
  • Proto-Oncogene Proteins c-met