Rationale and Preclinical Data Supporting Bariatric Arterial Embolization

Tech Vasc Interv Radiol. 2020 Mar;23(1):100656. doi: 10.1016/j.tvir.2020.100656. Epub 2020 Jan 11.

Abstract

The prevalence of obesity is increasing globally, leading to significantly increased morbidity, mortality, and health care costs. However, there is a lack of effective treatment options that can treat patients with obesity less invasively than with bariatric surgery. Bariatric arterial embolization (BAE) is an image-guided, minimally invasive, percutaneous procedure that is currently being investigated in preclinical animal models and early clinical trials. If successful, BAE may represent a viable interventional approach for obesity treatment. The purpose of this article is to introduce the physiological and anatomical rationale for BAE, review techniques involved in performing BAE for weight modulation, and provide up-to-date preclinical evidence that supports the translation of BAE into patients.

Keywords: Bariatric embolization; Embolics; Ghrelin; Obesity; Weight loss.

Publication types

  • Review

MeSH terms

  • Animals
  • Appetite Regulation
  • Embolization, Therapeutic* / adverse effects
  • Feeding Behavior
  • Gastric Artery*
  • Gastric Fundus / blood supply*
  • Ghrelin / metabolism
  • Humans
  • Obesity / metabolism
  • Obesity / physiopathology
  • Obesity / psychology
  • Obesity / therapy*
  • Signal Transduction
  • Translational Research, Biomedical
  • Treatment Outcome
  • Weight Loss

Substances

  • Ghrelin