Dopaminergic Control over the Tripartite Synapse

Jeroen P H Verharen; Johannes W de Jong; Stephan Lammel

doi:10.1016/j.neuron.2020.02.031

Dopaminergic Control over the Tripartite Synapse

Neuron. 2020 Mar 18;105(6):954-956. doi: 10.1016/j.neuron.2020.02.031.

Authors

Jeroen P H Verharen¹, Johannes W de Jong¹, Stephan Lammel²

Affiliations

¹ Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA. Electronic address: lammel@berkeley.edu.

Abstract

In this issue of Neuron, Corkrum et al. (2020) demonstrate an unexpected role for dopamine D₁ receptors on astrocytes located in the nucleus accumbens, a key structure of the brain's reward system. Activation of these receptors mediates dopamine-evoked depression of excitatory synaptic transmission, which contributes to amphetamine's psychomotor effects.

Keywords: amphetamine; astrocytes; dopamine; nucleus accumbens; reward.

Publication types

Comment

MeSH terms

Amphetamine
Astrocytes
Dopamine*
Nucleus Accumbens*
Synapses

Substances

Amphetamine
Dopamine

Abstract

Publication types

MeSH terms

Substances

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