iHWG-MOX: A Hybrid Breath Analysis System via the Combination of Substrate-Integrated Hollow Waveguide Infrared Spectroscopy with Metal Oxide Gas Sensors

ACS Sens. 2020 Apr 24;5(4):1033-1039. doi: 10.1021/acssensors.9b02554. Epub 2020 Mar 31.

Abstract

According to their materials and operating parameters, metal oxide (MOX) sensors respond to target gases only by a change in sensor resistance with a lack in selectivity. By the use of infrared spectroscopy, highly discriminatory information from samples at a molecular level can be obtained and the selectivity can be enhanced. A low-volume gas cell was developed for a commercially available semiconducting MOX methane gas sensor and coupled directly to a mid-infrared gas sensor based on substrate-integrated hollow waveguide (iHWG) technology combined with a Fourier transform infrared spectrometer. This study demonstrates a sensing process with combined orthogonal sensors for fast, time-resolved, and synergic detection of methane and carbon dioxide in gas samples.

Keywords: breath analysis; breath diagnostics; eNose; iHWG; metal oxide sensor; substrate-integrated hollow waveguide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • Breath Tests / methods*
  • Gases / analysis*
  • Humans
  • Spectrophotometry, Infrared / methods*

Substances

  • Gases