The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer

Anticancer Agents Med Chem. 2020;20(8):941-950. doi: 10.2174/1871520620666200318094618.

Abstract

Background: Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underlying mechanism of the altered metabolism in CRC is still unknown.

Methods: In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in 135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated.

Results: Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1 showed a significantly strong link with FOXM1 in CRC tissue.

Conclusion: Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.

Keywords: Colorectal cancer; FOXM1; GLUT1; altered metabolism; immunohistochemical staining; prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms / diagnosis*
  • Colorectal Neoplasms / metabolism
  • Female
  • Forkhead Box Protein M1 / genetics
  • Forkhead Box Protein M1 / metabolism*
  • Glucose Transporter Type 1 / genetics
  • Glucose Transporter Type 1 / metabolism*
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged

Substances

  • FOXM1 protein, human
  • Forkhead Box Protein M1
  • Glucose Transporter Type 1
  • SLC2A1 protein, human