A tri-metallic palladium complex with breast cancer stem cell potency

Arvin Eskandari; Arunangshu Kundu; Alice Johnson; Sanjib Karmakar; Sushobhan Ghosh; Kogularamanan Suntharalingam

doi:10.1039/d0dt00006j

A tri-metallic palladium complex with breast cancer stem cell potency

Dalton Trans. 2020 Apr 7;49(14):4211-4215. doi: 10.1039/d0dt00006j.

Authors

Arvin Eskandari¹, Arunangshu Kundu², Alice Johnson³, Sanjib Karmakar², Sushobhan Ghosh², Kogularamanan Suntharalingam³

Affiliations

¹ School of Pharmacy, University College London, London, UK.
² Department of Chemistry, Gauhati University, Guwahati, India. sushobhan.iisc@gmail.com.
³ School of Chemistry, University of Leicester, Leicester, UK. k.suntharalingam@leicester.ac.uk.

PMID: 32186576
DOI: 10.1039/d0dt00006j

Abstract

A multi-nuclear, triangular-shaped palladium(ii) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(ii) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology
Cell Line, Tumor
Cell Proliferation / drug effects
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Crystallography, X-Ray
DNA Damage
DNA, Neoplasm / drug effects
DNA, Neoplasm / genetics
Drug Screening Assays, Antitumor
Female
HEK293 Cells
Humans
Models, Molecular
Molecular Structure
Neoplastic Stem Cells / drug effects*
Palladium / chemistry
Palladium / pharmacology*

Substances

Antineoplastic Agents
Coordination Complexes
DNA, Neoplasm
Palladium