COX-2 in liver fibrosis

Hu Yang; Yang Xuefeng; Wu Shandong; Xiao Jianhua

doi:10.1016/j.cca.2020.03.024

COX-2 in liver fibrosis

Clin Chim Acta. 2020 Jul:506:196-203. doi: 10.1016/j.cca.2020.03.024. Epub 2020 Mar 14.

Authors

Hu Yang¹, Yang Xuefeng², Wu Shandong³, Xiao Jianhua⁴

Affiliations

¹ Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, China; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang 421001, Hunan, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China; Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, China.
² Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, China.
³ Department of Pharmacology, Faculty of Science, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.
⁴ Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, China; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang 421001, Hunan, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, Hunan, China. Electronic address: jhxiao223@163.com.

PMID: 32184095
DOI: 10.1016/j.cca.2020.03.024

Abstract

As a vital inducible sensor, cyclooxygenase-2 (COX-2) plays an important role in the progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can significantly accelerate the onset and development of liver fibrosis. COX-2 overexpression triggers inflammation that is an important inducer in hepatic fibrosis. Increasing evidence indicates that COX-2 is involved in the main pathogenesis of liver fibrosis, such as inflammation, apoptosis, and cell senescence. Moreover, COX-2 expression is altered in patients and animal models with non-alcoholic fatty liver disease or cirrhosis. These findings suggest that COX-2 has a broad and critical role in the development of liver fibrosis. In this review, we summarize the latest advances in the regulation and signal transduction of COX-2 and its impact on liver fibrosis.

Keywords: Autophagy; COX-2; Cell senescence; Inflammation; Liver fibrosis.

Publication types

Review

MeSH terms

Animals
Cyclooxygenase 2* / genetics
Cyclooxygenase 2* / metabolism
Humans
Liver Cirrhosis / metabolism*
Signal Transduction / genetics

Substances

Cyclooxygenase 2