Context-Dependent Immune Responses Explain Pancreatic Cancer Immunoresistance

Filip Bednar; Marina Pasca di Magliano

doi:10.1016/j.ccell.2020.02.010

Context-Dependent Immune Responses Explain Pancreatic Cancer Immunoresistance

Cancer Cell. 2020 Mar 16;37(3):261-263. doi: 10.1016/j.ccell.2020.02.010.

Authors

Filip Bednar¹, Marina Pasca di Magliano²

Affiliations

¹ Department of Surgery, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.
² Department of Surgery, University of Michigan, Ann Arbor, MI, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: marinapa@med.umich.edu.

PMID: 32183944
DOI: 10.1016/j.ccell.2020.02.010

Abstract

Immunotherapy is standard of care for many malignancies, including non-small cell lung cancer, but its benefits have not extended to pancreatic cancer. In this issue of Cancer Cell, DeNardo and colleagues investigate the differences in immune response in lung and pancreas and potential approaches to overcome immunoresistance in the latter.

Publication types

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MeSH terms

Carcinoma, Non-Small-Cell Lung*
Dendritic Cells
Humans
Immunologic Surveillance
Immunotherapy
Lung Neoplasms*
Pancreatic Neoplasms*