Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets

Roslyn M Ray; Kevin V Morris

doi:10.3390/ncrna6010012

Long Non-coding RNAs Mechanisms of Action in HIV-1 Modulation and the Identification of Novel Therapeutic Targets

Noncoding RNA. 2020 Mar 13;6(1):12. doi: 10.3390/ncrna6010012.

Authors

Roslyn M Ray¹, Kevin V Morris¹

Affiliation

¹ The Center for Gene Therapy, The Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA.

Abstract

This review aims to highlight the role of long non-coding RNAs in mediating human immunodeficiency virus (HIV-1) viral replication, latency, disease susceptibility and progression. In particular, we focus on identifying possible lncRNA targets and their purported mechanisms of action for future drug design or gene therapeutics.

Keywords: HIV; antisense; epigenetic; lncRNA; transcription.

Publication types

Review

Abstract

Publication types

Grants and funding