Abstract
The innate immune receptor Mincle senses lipid-based molecules derived from pathogens, commensals and altered self. Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-β-d-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.
MeSH terms
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Animals
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Cholesterol / analogs & derivatives*
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Cholesterol / pharmacology*
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Glucosides / chemical synthesis
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Glucosides / pharmacology*
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Humans
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Lectins, C-Type / agonists*
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Mice
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Receptors, Immunologic / agonists*
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Signal Transduction / drug effects*
Substances
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CLEC4D protein, human
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Glucosides
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Lectins, C-Type
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Receptors, Immunologic
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Cholesterol