Adult worm exclusion and histological data of dogs repeatedly infected with the cestode Echinococcus multilocularis

Hirokazu Kouguchi; Hidefumi Furuoka; Takao Irie; Jun Matsumoto; Ryo Nakao; Nariaki Nonaka; Yasuyuki Morishima; Kazuhiro Okubo; Kinpei Yagi

doi:10.1016/j.dib.2020.105353

Adult worm exclusion and histological data of dogs repeatedly infected with the cestode Echinococcus multilocularis

Data Brief. 2020 Mar 2:29:105353. doi: 10.1016/j.dib.2020.105353. eCollection 2020 Apr.

Authors

Hirokazu Kouguchi¹, Hidefumi Furuoka², Takao Irie¹, Jun Matsumoto³, Ryo Nakao⁴, Nariaki Nonaka⁴, Yasuyuki Morishima⁵, Kazuhiro Okubo¹, Kinpei Yagi¹

Affiliations

¹ Department of Infectious Diseases, Hokkaido Institute of Public Health, N19 W12, Kita-Ku, Sapporo, Hokkaido, 060-0819, Japan.
² Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan.
³ Laboratory of Medical Zoology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa 252-0880, Japan.
⁴ Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, 001-0020, Japan.
⁵ Department of Parasitology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.

Abstract

The data presented in this article are related to a previously published research article titled "The timing of worm exclusion in dogs repeatedly infected with the cestode Echinococcus multilocularis" (2016) [1]. This data describe a comparison of worm exclusion in the early stage of infection (1 day and 6 days post-infection) between dogs infected for the first time (control group) and dogs repeatedly infected with the parasite 4 times (repeated infection groups). We observed that 6 days post reinfection, the number of adult worms in repeated-infection groups decreased by 88.7% compared with the control group. Histological analysis comparison of the small intestinal mucosa from healthy, first infected, and repeatedly infected dogs are also reported. We observed no clear pathological abnormality, except the shortening of microvillus in reinfected dogs. However, eosinophil accumulation and eosinophilic ulcers were observed in some reinfected dogs. This data could be useful as preliminary data to develop a final host vaccine for this parasite.

Keywords: Dog; Echinococcus multilocularis; Final host; Histological analysis; Mucosal immunity; Repeated infection; Vaccine.