A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption

Michael J Peluso; Lynda Dee; Danielle Campbell; Jeff Taylor; Rebecca Hoh; Rachel L Rutishauser; John Sauceda; Steven G Deeks; Karine Dubé

A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption

J Virus Erad. 2020 Feb 20;6(1):34-37.

Authors

Michael J Peluso¹, Lynda Dee^{2

3

4

5}, Danielle Campbell^{3

4

5

6}, Jeff Taylor^{3

5

7

8}, Rebecca Hoh¹, Rachel L Rutishauser⁹, John Sauceda¹⁰, Steven G Deeks¹, Karine Dubé¹¹

Affiliations

¹ Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
² AIDS Action Baltimore, Baltimore, MD, USA.
³ amfAR Institute for HIV Cure Research Community Advisory Board, USA.
⁴ Delaney AIDS Research Enterprise Community Advisory Board, USA.
⁵ Martin Delaney Collaboratory Community Advisory Board, USA.
⁶ Charles R Drew University of Medicine and Science, Los Angeles, CA, USA.
⁷ University of California, San Diego Antiviral Research Center Community Advisory Board, San Diego, CA, USA.
⁸ HIV+Aging Research Project, Palm Springs, CA, USA.
⁹ Division of Experimental Medicine, UCSF, San Francisco, CA, USA.
¹⁰ Center for AIDS Prevention Studies, UCSF, San Francisco, CA, USA.
¹¹ UNC Gillings School of Global Public Health, Chapel Hill, NC, USA.

PMID: 32175090
PMCID: PMC7043899

Abstract

Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s). Two documented HIV transmissions occurring in the context of ATIs have been recently reported, but recommendations for mitigating the risk of such events during ATIs are limited. We outline a practical approach to risk mitigation during ATI studies and describe strategies we are utilising in an upcoming clinical trial that may be applicable to other centres.

Keywords: HIV; HIV cure research; HIV remission research; analytical treatment interruption.

Publication types

Editorial

Abstract

Publication types

Grants and funding