The key role of oncopharmacology in therapeutic management, from common to rare cancers: A literature review

Abstract

The therapeutic management of cancers has undergone considerable changes due to the emergence of genomics tools and tumor molecular deciphering. In this context, a dual pharmacological approach based on pharmacogenomic analyses and therapeutic drug monitoring is now part of the routine care in cancer management for personalized therapies. First, molecular and immune profiling of tumors allows the emergence of new pharmacological targets in common as well as in rare cancers. Second, pharmacogenomic analyses coupled to therapeutic drug monitoring guide the prescription by adjusting regimen and managing drug resistance.

Keywords: Immunotherapies; Oncopharmacology; Pharmacogenomics; Resistance; Targeted therapies; Therapeutic drug monitoring.