Presence of guanidinoacetate may compensate creatine absence and account for less statin-induced muscle damage in GAMT-deficient compared to AGAT-deficient mice

Amino Acids. 2020 Apr;52(4):667-669. doi: 10.1007/s00726-020-02838-z. Epub 2020 Mar 14.

Authors

Maurizio Balestrino^{1

2}, Enrico Adriano³

Affiliations

¹ Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother and Child Sciences (DINOGMI), University of Genoa, Genoa, Italy. mbalestrino@neurologia.unige.it.
² IRCCS Ospedale Policlinico San Martino, Genoa, Italy. mbalestrino@neurologia.unige.it.
³ Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother and Child Sciences (DINOGMI), University of Genoa, Genoa, Italy.

PMID: 32172372
DOI: 10.1007/s00726-020-02838-z

No abstract available

Publication types

Letter

MeSH terms

Amidinotransferases / deficiency*
Amidinotransferases / metabolism
Amino Acid Metabolism, Inborn Errors / metabolism*
Animals
Creatine / deficiency*
Creatine / metabolism
Creatine / therapeutic use
Developmental Disabilities / metabolism
Glycine / analogs & derivatives*
Glycine / deficiency
Glycine / metabolism
Glycine / therapeutic use
Guanidinoacetate N-Methyltransferase / deficiency*
Guanidinoacetate N-Methyltransferase / metabolism
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / toxicity
Intellectual Disability / metabolism*
Language Development Disorders / metabolism*
Mice
Movement Disorders / congenital*
Movement Disorders / metabolism
Muscular Diseases / chemically induced
Muscular Diseases / drug therapy*
Muscular Diseases / metabolism
Phosphorylation
Speech Disorders / metabolism*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Guanidinoacetate N-Methyltransferase
Amidinotransferases
glycocyamine
Creatine
Glycine

Supplementary concepts

Arginine-Glycine Amidinotransferase Deficiency
Guanidinoacetate methyltransferase deficiency