Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii

Lulu Li; Long Chen; Yuhuan Li; Shikai Sun; Shuanggang Ma; Yong Li; Jing Qu

doi:10.1016/j.phytochem.2020.112343

Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii

Phytochemistry. 2020 Jun:174:112343. doi: 10.1016/j.phytochem.2020.112343. Epub 2020 Mar 13.

Authors

Lulu Li¹, Long Chen¹, Yuhuan Li², Shikai Sun¹, Shuanggang Ma¹, Yong Li¹, Jing Qu³

Affiliations

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
² Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
³ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: qujing@imm.ac.cn.

PMID: 32172016
DOI: 10.1016/j.phytochem.2020.112343

Abstract

Detailed phytochemical investigation of the roots of Erythrophleum fordii furnished seven undescribed cassane-type diterpenoids, erythrocassanoids A-E and erythro-norcassanoids A, B and two known clerodane diterpenes, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid. Their structures were determined by 1D, 2D NMR and HRESIMS analysis. The antiviral activities of these compounds were evaluated. Among them, 15-hydroxy-3-cleroden-2-one and methyl ester of 2-oxopopulifolic acid showed antiviral activities against influenza virus and coxsackie virus with IC₅₀ values ranging from 11.11 to 29.60 μM.

Keywords: Antiviral activity; Cassane diterpenoids; Erythrophleum fordii (Leguminosae).

MeSH terms

Diterpenes*
Diterpenes, Clerodane*
Fabaceae*
Molecular Structure
Phytochemicals
Plant Roots

Substances

Diterpenes
Diterpenes, Clerodane
Phytochemicals