Isolation of benzolactones, Ganodumones A-F from Ganoderma lucidum and their antibacterial activities

Bioorg Chem. 2020 May:98:103723. doi: 10.1016/j.bioorg.2020.103723. Epub 2020 Mar 3.

Abstract

Six previously undescribed benzolactone constituents, ganodumones A-F (1-6), a new type of Ganoderma meroterpenoids (GMs) fused with 1,2,3,4,5-pentasubstituted phenyl and 1',2'-dioxy-3'-methyl-pentyl chain were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were determined by spectroscopic analysis, X-ray crystal diffraction, and ECD computational methods. Meanwhile, bioactive evaluation showed that compounds 3 and 5 have antibacterial activities against Microsporum gypseum with MIC90 56.86 ± 3.98 and 18.48 ± 0.47 μg/mL, respectively.

Keywords: Antibacterial activities; Benzolactone; Ganoderma; Ganoderma meroterpenoids; Microsporum gypseum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology*
  • Arthrodermataceae / drug effects*
  • Crystallography, X-Ray
  • Dose-Response Relationship, Drug
  • Fruiting Bodies, Fungal / chemistry
  • Ganoderma / chemistry*
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Conformation
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Lactones

Supplementary concepts

  • Nannizzia gypsea