FSH signaling is involved in affective disorders

Wen-Kai Bi; Si-Si Luan; Jing Wang; Shan-Shan Wu; Xin-Chen Jin; Yi-Lin Fu; Ling Gao; Jia-Jun Zhao; Zhao He

doi:10.1016/j.bbrc.2020.03.039

FSH signaling is involved in affective disorders

Biochem Biophys Res Commun. 2020 May 14;525(4):915-920. doi: 10.1016/j.bbrc.2020.03.039. Epub 2020 Mar 11.

Authors

Wen-Kai Bi¹, Si-Si Luan¹, Jing Wang¹, Shan-Shan Wu¹, Xin-Chen Jin¹, Yi-Lin Fu¹, Ling Gao², Jia-Jun Zhao³, Zhao He⁴

Affiliations

¹ Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicine, Ji-nan, 25000, China; School of Medicine, Shandong University, Ji-nan, 25000, China.
² Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicine, Ji-nan, 25000, China.
³ Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicine, Ji-nan, 25000, China; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Ji-nan, 25000, China. Electronic address: jjzhao@sdu.edu.cn.
⁴ Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Ji-nan, 25000, China; Shandong Provincial Key Laboratory of Endocrinology and Lipid Metabolism, Ji-nan, 25000, China; Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Medicine, Ji-nan, 25000, China; School of Medicine, Shandong University, Ji-nan, 25000, China; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University & Shandong Academy of Medical Sciences, Ji-nan, 25000, China. Electronic address: zhaohe7711@qq.com.

PMID: 32171529
DOI: 10.1016/j.bbrc.2020.03.039

Abstract

Affective disorders are a set of mental disorders and particularly disrupt the mental health of susceptible women during puberty, pregnancy, parturition and menopause transition, which are characterized by dramatic changes in reproductive hormone profiles. The serum FSH level changes significantly during these periods; yet, the role of FSH in mood regulation is poorly understood. In the current study, FSHR knockout (Fshr^-/-) mice displayed enhanced affective disorder behaviors in an open field test and a forced swim test, accompanied by altered gene expression profiles. The differentially expressed genes between Fshr^-/- mice and Fshr^+/+ mice were enriched in multiple neuroendocrine metabolic pathways. FSHR deletion significantly increased/decreased the mRNA and/or protein expression levels of AOX1, RDH12, HTR3a and HTR4 in mood-mediating brain regions, including the hippocampus and prefrontal cortex. These results reveal that FSH signaling is involved in the development of affective disorders.

Keywords: Affective disorders; Anxiety; Depression; FSH.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohol Oxidoreductases / genetics
Alcohol Oxidoreductases / metabolism
Aldehyde Oxidase / genetics
Aldehyde Oxidase / metabolism
Animals
Behavior, Animal
Female
Follicle Stimulating Hormone / metabolism*
Hippocampus / physiology*
Mice, Inbred C57BL
Mice, Knockout
Mood Disorders / genetics
Mood Disorders / metabolism*
Prefrontal Cortex / physiology*
Receptors, FSH / genetics
Receptors, FSH / metabolism*
Receptors, Serotonin, 5-HT3 / genetics
Receptors, Serotonin, 5-HT3 / metabolism
Signal Transduction
Transcriptome

Substances

Htr3a protein, mouse
Receptors, FSH
Receptors, Serotonin, 5-HT3
Follicle Stimulating Hormone
Alcohol Oxidoreductases
Rdh12 protein, mouse
Aldehyde Oxidase
Aox1 protein, mouse