Objective: To determine the regular changes of blood coagulation indices in twin pregnancy complicated with preeclampsia (PE).
Study design: Descriptive study.
Place and duration of study: Fujian Provincial Maternity and Children Hospital from January 2014 to December 2017.
Methodology: A total of 180 twin pregnancies were enrolled in this study, including 40 diagnosed as PE, 50 as severe PE (SPE), and 90 as normal twin pregnancies. The changes of coagulation parameters of twin pregnant women in different gestational states and periods were retrospectively analysed.
Results: During the middle and late pregnancies in all groups, the PT (prothrombin time) decreased, and D-Di (D-dimers) increased gradually compared to early pregnancy (p <0.05). When D-Di increased abnormally, adverse pregnancy outcomes increased. APTT (activated partial thromboplastin time) and TT (thromoplastin time) were shortened first and then significantly prolonged (p <0.05). In the normal twin group, FIB was increased gradually from early pregnancy to midlate pregnancy; in the PE group, FIB was increased and then decreased, especially in the sPE group (p <0.05). There was no significant difference in coagulation function in early pregnancy (p >0.05). FIB in sPE group was lower than that in other two groups in late pregnancy. TT in sPE group was higher than that in other two groups. D-Di and APTT in PE group and sPE group were higher than those in normal group (p <0.05). The TT sensitivity was 68.8% with specificity 72.4%, at cut-off value of 13.48 s (p <0.01).
Conclusion: The regular changes of blood coagulation indices in twin pregnancy complicated with PE had great predictive and diagnostic value of preeclampsia.