Tumor-targeted near-infrared fluorophore for fluorescence-guided phototherapy

Chem Commun (Camb). 2020 Apr 14;56(30):4180-4183. doi: 10.1039/d0cc01366h.

Abstract

A tumor-targeted near-infrared (NIR) fluorophore CA800SO3 was developed for fluorescence-guided phototherapy. This new type of NIR fluorophore showed high tumor targetability based on the structure-inherent targeting approach. This fluorophore generated sufficient hyperthermia and reactive oxygen species (ROS) simultaneously for synergistic cancer phototherapy, induced by an 808 nm laser irradiation.

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Fluorescence*
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Humans
  • Infrared Rays
  • Mice
  • Molecular Structure
  • Neoplasms / diagnostic imaging*
  • Neoplasms / therapy*
  • Neoplasms, Experimental / diagnostic imaging
  • Neoplasms, Experimental / therapy
  • Particle Size
  • Phototherapy*
  • Surface Properties

Substances

  • Fluorescent Dyes