Research progress in the application of in situ hydrogel system in tumor treatment

Weipeng Wei; Hongfang Li; Chengchen Yin; Fushan Tang

doi:10.1080/10717544.2020.1739171

Research progress in the application of in situ hydrogel system in tumor treatment

Drug Deliv. 2020 Dec;27(1):460-468. doi: 10.1080/10717544.2020.1739171.

Authors

Weipeng Wei^{1

2

3}, Hongfang Li^{1

2

3}, Chengchen Yin^{1

2

3}, Fushan Tang^{1

2

3}

Affiliations

¹ Department of Clinical Pharmacy, School of Pharmacy, Zunyi Medical University, Zunyi, China.
² The Key Laboratory of Clinical Pharmacy in Zunyi City, Zunyi, China.
³ Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China.

Abstract

The in situ hydrogel drug delivery system is a hot research topic in recent years. Combining both properties of hydrogel and solution, in situ hydrogels can provide many advantages for drug delivery application, including easy application, high local drug concentration, prolonged drug retention time, reduced drug dose in vivo, good biocompatibility and improved patient compliance, thus has potential in tumor treatment. In this paper, the related literature reports in recent years were reviewed to summarize and discuss the research progress and development prospects in the application of in situ hydrogels in tumor treatment.

Keywords: In situ hydrogel; drug delivery system; progress; tumor treatment.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / pharmacokinetics
Drug Delivery Systems*
Humans
Hydrogels
Medication Adherence
Neoplasms / drug therapy*

Substances

Antineoplastic Agents
Hydrogels

Grants and funding

This work was supported by grants from the National Natural Science Foundation of China (NO: 31460246), the Guizhou Provincial Science and Technology Foundation (NO: Qiankehe LH [2014] 7564), the Project of Special Funds for Science and Technology Cooperation in Guizhou Provinces and Zunyi City (Shengshikehe [2015] 53), the Education Department of Guizhou Province (GNYL (2017) 006 and YLXKJS-YS-05), Collaborative Innovation Center of Guizhou Traditional Chinese Medicine and Ethnic medicine (NO: Qianjiaokeyanfa [2012] 311).