Epigenetics, chromatin and brain development and function

Brain Neurosci Adv. 2018 Nov 12:2:2398212818812011. doi: 10.1177/2398212818812011. eCollection 2018 Jan-Dec.

Abstract

Research investigating epigenetics and chromatin function in brain and behaviour has mushroomed over the last two decades. And yet epigenetics as a biological concept predates the discovery in the 1950s of DNA as the principle mode of inheritance by over a decade. This review explores the past, present and future research into epigenetics as it relates to understanding brain development and function.

Keywords: DNA methylation; epigenome editing; genomic imprinting; histones; memory; single cell.

Publication types

  • Review