Type I Interferons Rule with an Iron Fist

Diego C P Rossi; George S Deepe Jr

doi:10.1016/j.chom.2020.02.007

Type I Interferons Rule with an Iron Fist

Cell Host Microbe. 2020 Mar 11;27(3):317-319. doi: 10.1016/j.chom.2020.02.007.

Authors

Diego C P Rossi¹, George S Deepe Jr²

Affiliations

¹ Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
² Division of Infectious Diseases, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA. Electronic address: george.deepe@uc.edu.

PMID: 32164842
DOI: 10.1016/j.chom.2020.02.007

Abstract

Pathogens rely on nutrient assimilation, particularly essential metal incorporation, to successfully survive in the host. In this issue of Cell Host & Microbe, Riedelberger et al. (2020) convincingly demonstrate that type I interferons (IFNs-I) promote dysregulation of iron homeostasis in macrophages upon infection with Candida glabrata and exacerbate infection.

Publication types

Comment

MeSH terms

Candida glabrata
Candidiasis*
Homeostasis
Humans
Interferon Type I*
Iron

Substances

Interferon Type I
Iron