Feeling the Burn: Intestinal Epithelial Cells Modify Their Lipid Metabolism in Response to Bacterial Fermentation Products

Jia Wen; John F Rawls

doi:10.1016/j.chom.2020.02.009

Feeling the Burn: Intestinal Epithelial Cells Modify Their Lipid Metabolism in Response to Bacterial Fermentation Products

Cell Host Microbe. 2020 Mar 11;27(3):314-316. doi: 10.1016/j.chom.2020.02.009.

Authors

Jia Wen¹, John F Rawls²

Affiliations

¹ Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA.
² Department of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: john.rawls@duke.edu.

PMID: 32164841
DOI: 10.1016/j.chom.2020.02.009

Abstract

Intestinal epithelial absorption of dietary lipids is a major determinant of animal energy balance and metabolic health. Recent studies uncovered significant roles for intestinal microbiota in this process, but underlying mechanisms remain unresolved. Araújo et al. (2020) identify two end-products of bacterial fermentation that regulate intestinal lipid absorption and metabolism.

Publication types

Comment

MeSH terms

Animals
Bacteria
Enterocytes*
Epithelial Cells
Fermentation
Lipid Metabolism*

Grants and funding

R01 DK081426/DK/NIDDK NIH HHS/United States