Introduction: A new solid-phase microextraction fibre is fabricated through polymerisation of molecularly imprinted polymer on the surface of a layered double hydroxide framework that has been fabricated via the in situ synthesis on a non-porous anodic aluminium oxide/aluminium wire as both the substrate and the aluminium source.
Objective: The synthesized SPME fiber was performed to analyze trace digoxin in real samples.
Material and method: A one-at-a-time optimization strategy was applied for optimizing the important extraction parameters such as extraction solvent, extraction time, stirring rate, pH, ionic strength, and desorption time.
Result: Aluminum surface before and after anodizing and LDH structure reveal that anodizing and preparation LDH increases the surface area and adsorption capacity of aluminum wire.
Conclusion: Under optimum conditions, the repeatability for one fibre (n = 3), expressed as relative standard deviation (RSD %), was 5.2%.
Keywords: aluminium wire; digoxin; layered double hydroxide; molecularly imprinted polymer; solid-phase microextraction.
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