Evaluation of the biological potential of ruthenium(II) complexes with cinnamic acid

J Inorg Biochem. 2020 May:206:111021. doi: 10.1016/j.jinorgbio.2020.111021. Epub 2020 Feb 14.

Abstract

In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula [Ru(L)(dppb)(bipy)]PF6, where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor cells from the lines MCF-7, MDA-MB-231 and in human (MCF-10A) or mouse (L929) non-tumor cells. Complexes Ru(L4)(dppb)(bipy)]PF6 (4) (L4 = 4-hydroxycinnamic acid) and [Ru(L5)(dppb)(bipy)]PF6 (5) (L5 = 3,4-dihydroxycinnamic acid) were the most selective, presenting the highest values of selectivity indexes besides inhibited some processes related to tumor progression in vitro, such as invasion, migration, and adhesion in the MDA-MB-231 cell line. In addition, the complexes 4 and 5 were able to interact with Bovine Serum Albumin (BSA) and complex 5 showed antioxidant activity.

Keywords: Antimetastatic potential; Antioxidant activity; Cinnamic acids; Ruthenium complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Biphenyl Compounds / chemistry
  • Cattle
  • Cell Adhesion
  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Cinnamates / chemistry*
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Fibroblasts / drug effects
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology*
  • Humans
  • Mice
  • Models, Molecular
  • Picrates / chemistry
  • Ruthenium Compounds / chemistry
  • Ruthenium Compounds / pharmacology*
  • Serum Albumin, Bovine / metabolism*
  • Triple Negative Breast Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents
  • Biphenyl Compounds
  • Cinnamates
  • Coordination Complexes
  • Free Radical Scavengers
  • Picrates
  • Ruthenium Compounds
  • cinnamic acid
  • Serum Albumin, Bovine
  • 1,1-diphenyl-2-picrylhydrazyl