Abstract
Two new helvolic acid analogues (1 and 2) and one new fumagillin derivative containing an octahydroisobenzofuran moiety (3), together with four known compounds (4-7), were isolated from an Aspergillus terreus, isolated from soil collected from Mauna Kea, the highest mountain in Hawaii. Compound 4 was recorded in SciFinder with a CAS Registry Number of 1379525-35-5, but it was not documented in the cited reference (ACS Chem. Biol. 2012, 7, 137). The structures of compounds 1-4 were elucidated by NMR spectroscopy and HRMS and ECD analysis. Compounds 5 and 6 showed significant inhibitory activity against NF-κB with IC50 values of 2.7 ± 2.6 and 6.5 ± 0.8 μM, respectively. Compounds 1 and 2 were active against S. aureus with MICs of 6.25 and 6.25 μg/mL, respectively, while compound 5 inhibited E. coli with an MIC of 3.12 μg/mL.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Aspergillus / chemistry*
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Cyclohexanes / isolation & purification
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Cyclohexanes / pharmacology*
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Escherichia coli / drug effects
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Fatty Acids, Unsaturated / isolation & purification
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Fatty Acids, Unsaturated / pharmacology*
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Fusidic Acid / analogs & derivatives*
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Fusidic Acid / isolation & purification
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Fusidic Acid / pharmacology
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HEK293 Cells
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Hawaii
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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NF-kappa B / antagonists & inhibitors*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Biological Products
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Cyclohexanes
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Fatty Acids, Unsaturated
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NF-kappa B
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Sesquiterpenes
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Fusidic Acid
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fumagillin
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helvolic acid