Digging deeper into volatile organic compounds associated with cancer

Sajjad Janfaza; Babak Khorsand; Maryam Nikkhah; Javad Zahiri

doi:10.1093/biomethods/bpz014

Digging deeper into volatile organic compounds associated with cancer

Biol Methods Protoc. 2019 Nov 27;4(1):bpz014. doi: 10.1093/biomethods/bpz014. eCollection 2019.

Authors

Sajjad Janfaza^{1

2}, Babak Khorsand³, Maryam Nikkhah², Javad Zahiri⁴

Affiliations

¹ School of Engineering, University of British Columbia, Kelowna, BC, Canada.
² Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran 14117, Iran.
³ Department of Computer Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
⁴ Bioinformatics and Computational Omics Lab (BioCOOL), Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran 14117, Iran.

Abstract

Volatile organic compounds (VOCs), produced and emitted through the metabolism of cancer cells or the body's immune system, are considered novel cancer biomarkers for diagnostic purposes. Of late, a large number of work has been done to find a relationship between VOCs' signature of body and cancer. Cancer-related VOCs can be used to detect several types of cancers at the earlier stages which in turn provide a significantly higher chance of survival. Here we aim to provide an updated picture of cancer-related VOCs based on recent findings in this field focusing on cancer odor database.

Keywords: aldehydes; cancer diagnosis; cancer odor; lung cancer; volatile organic compounds.

Publication types

Review