PSPC1: a contextual determinant of tumor progression

Yaw-Dong Lang; Yuh-Shan Jou

doi:10.1080/23723556.2020.1721253

PSPC1: a contextual determinant of tumor progression

Mol Cell Oncol. 2020 Feb 3;7(2):1721253. doi: 10.1080/23723556.2020.1721253. eCollection 2020.

Authors

Yaw-Dong Lang¹, Yuh-Shan Jou¹

Affiliation

¹ Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Abstract

Protein-tyrosine kinase 6 (PTK6) sequestrated by its substrate paraspeckle component 1 (PSPC1) in nucleus is a tumor suppressor. PSPC1 functions as a contextual determinant of oncogenic subcellular translocations to synergize PSPC1/β-catenin and PTK6 tumorigenesis. Besides, PSPC1 C-terminal interacting domain (PSPC1-CT131), a dual inhibitor of PSPC1 and PTK6, suppresses cancer progression.

Keywords: CSC; EMT; HCC; Oncogenic subcellular translocation; metastasis.

Grants and funding

Our work was supported by Academia Sinica and Ministry of Science and Technology of Taiwan (MOST 107-0210-01-19-01, 106-0210-01-15-02, 107-2321-B-001-025 and 104-2320-B-001-009-MY3).