New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma

Mirentxu Santos

doi:10.1080/23723556.2019.1702413

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma

Mol Cell Oncol. 2020 Jan 7;7(2):1702413. doi: 10.1080/23723556.2019.1702413. eCollection 2020.

Author

Mirentxu Santos^{1

2

3}

Affiliations

¹ Basic Research Department, Molecular Oncology Unit, Madrid, Spain.
² Basic Research Department, CIBERONC, Centro de Investigación Biomédica en Red de Cáncer, Spain.
³ Basic Research Department, Institute of Biomedical Research University Hospital, Madrid, Spain.

Abstract

High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB transcriptional corepressor 1), Rbl1 (RB transcriptional corepressor like 1), Pten (phosphatase and tensin homolog), Trp53 (transformation-related protein 53), which provide a suitable frame for preclinical intervention. A defined model for LCNEC had not been previously reported.

Keywords: LCNEC; Lung cancer; Pten; Rb1; Rbl1; SCLC; Trp53; cell of origin; molecular imaging; tumor suppressors.

Grants and funding

This work was funded by projects PI12/01959, PI15/00993, PI18/000263, and CIBERONC CB/16/00228 from the Instituto de Salud Carlos III (Ministry of Science, Innovation and Universities) and cofunded by the European Regional Development Fund.