Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

Mortezazadeh T; Gholibegloo E; Riyahi Alam N; Haghgoo S; Musa A E; Khoobi M

doi:10.31661/jbpe.v0i0.1018

Glucosamine Conjugated Gadolinium (III) Oxide Nanoparticles as a Novel Targeted Contrast Agent for Cancer Diagnosis in MRI

J Biomed Phys Eng. 2020 Feb 1;10(1):25-38. doi: 10.31661/jbpe.v0i0.1018. eCollection 2020 Feb.

Authors

Mortezazadeh T^{1

2}, Gholibegloo E³, Riyahi Alam N¹, Haghgoo S⁴, Musa A E¹, Khoobi M³

Affiliations

¹ PhD, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.
² PhD, Department of Medical Physics, School of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
³ PhD, Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center (MBRC), Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁴ PhD, Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health, Tehran, Iran.

Abstract

Background: Glucose transporter (Glut), a cellular transmembrane receptor, has a key role in the metabolism of cell glucose and is also associated with various human carcinomas.

Objective: In this study, we evaluated a magnetic resonance (MR) imaging contrast agent for tumor detection based on paramagnetic gadolinium oxide (Gd₂O₃) coated polycyclodextrin (PCD) and modified with glucose (Gd₂O₃@PCD-Glu) for the targeting of overexpressed glucose receptors.

Material and methods: In this experimental study, 3T magnetic resonance imaging (MRI) scanner was used to assess the specific interactions between Glut1-overexpressing tumor cells (MDA-MB-231) and Gd₂O₃@PCD-Glu NPs. Furthermore, the capacity of transporting Gd₂O₃@PCD-Glu NPs to tumor cells was evaluated.

Results: It was found that the acquired MRI T₁ signal intensity of MDA-MB-231 cells that were treated with the Gd₂O₃@PCD-Glu NPs increased significantly. Based on the results obtained, Gd₂O₃@PCD-Glu NPs can be applied in targeting Glut1-overexpressing tumor cells in vivo, as well as an MRI-targeted tumor agent to enhance tumor diagnosis.

Conclusion: Results have shown that glucose-shell of magnetic nanoparticles has a key role in diagnosing cancer cells of high metabolic activity.

Keywords: Contrast media; Gadolinium; Magnetic Resonance Imaging.