Neural Stem/Progenitor Cells of Human Olfactory Mucosa for the Treatment of Chronic Spinal Cord Injuries

Bull Exp Biol Med. 2020 Feb;168(4):538-541. doi: 10.1007/s10517-020-04749-1. Epub 2020 Mar 10.

Abstract

We studied the efficiency of transplantation of neural stem/progenitor cells from human olfactory mucosa in chronic spinal cord injury. Neural stem/progenitor cells were obtained by a protocol modified by us and transplanted to rats with spinal post-traumatic cysts. It was shown that transplantation of neural stem/progenitor cells from human olfactory lining improved motor activity of hind limbs in the recipient rat with spinal post-traumatic cysts (according to BBB scale).

Keywords: cell therapy; human olfactory mucosa; neural stem/progenitor cells; spinal cord injuries.

MeSH terms

  • Animals
  • Chronic Disease
  • Hindlimb
  • Humans
  • Motor Activity / physiology*
  • Nasal Cavity / cytology
  • Nasal Cavity / surgery
  • Neural Stem Cells / cytology
  • Neural Stem Cells / physiology
  • Neural Stem Cells / transplantation*
  • Olfactory Mucosa / cytology
  • Olfactory Mucosa / surgery
  • Primary Cell Culture
  • Rats
  • Rats, Wistar
  • Recovery of Function*
  • Spinal Cord / surgery
  • Spinal Cord Injuries / pathology
  • Spinal Cord Injuries / surgery
  • Spinal Cord Injuries / therapy*
  • Stem Cell Transplantation*
  • Transplantation, Heterologous