Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report

Eric C Keen; Preston Tasoff; Tiffany Hink; Kimberly A Reske; Carey-Ann D Burnham; Gautam Dantas; Jennie H Kwon; Erik R Dubberke

doi:10.1093/ofid/ofaa042

Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report

Open Forum Infect Dis. 2020 Feb 11;7(3):ofaa042. doi: 10.1093/ofid/ofaa042. eCollection 2020 Mar.

Authors

Eric C Keen^{1

2}, Preston Tasoff^{1

2}, Tiffany Hink³, Kimberly A Reske³, Carey-Ann D Burnham^{2

3

4

5}, Gautam Dantas^{1

2

5

6}, Jennie H Kwon³, Erik R Dubberke³

Affiliations

¹ The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
² Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
³ Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
⁴ Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
⁵ Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
⁶ Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.

Abstract

A 62-year-old woman received RBX2660, an investigational microbiome restoration therapeutic, for recurrent multidrug-resistant (MDR) urinary tract infection (UTI). RBX2660 increased gut microbiome diversity but did not eliminate uropathogen carriage, and MDR UTI recurred after subsequent antibiotic exposure. Thus, restoration of microbiome diversity does not preclude disease recurrence by residual MDR pathogens.

Keywords: antibiotic resistance; fecal microbiota transplant; microbial restoration therapy; microbiome; urinary tract infection.

Abstract

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