Polymeric worm-like nanomicellar system for accelerated wound healing

Aarti Singh; Adeeba Shakeel; Dakshi Kochhar; Sampathkumar Jeevanandham; Satyendra Kumar Rajput; Monalisa Mukherjee

doi:10.4103/japtr.JAPTR_153_19

Polymeric worm-like nanomicellar system for accelerated wound healing

J Adv Pharm Technol Res. 2020 Jan-Mar;11(1):36-43. doi: 10.4103/japtr.JAPTR_153_19.

Authors

Aarti Singh¹, Adeeba Shakeel², Dakshi Kochhar^{1

3}, Sampathkumar Jeevanandham^{1

4}, Satyendra Kumar Rajput⁵, Monalisa Mukherjee^{1

3}

Affiliations

¹ Amity Institute of Click Chemistry Research and Studies, Amity University, Noida, Uttar Pradesh, India.
² All India Institute of Medical Sciences, New Delhi, India.
³ Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
⁴ Amity Institute of Nanotechnology, Amity University, Noida, Uttar Pradesh, India.
⁵ Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.

Abstract

Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems - a material with ample potential for wound healing applications - to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (DEAEMA-co-AAc) (PDEA) is examined with a cutaneous excisional wound model alterations in wound size, and histological assessments revealed a higher wound healing rate, including dermis proliferation, re-epithelialization, reduced scar formation, and anti-inflammatory properties. Moreover, a mechanism for the formation of spherical and worm-like micelles (WLMs) is delineated using a suite of characterizations. The excellent porosity and ability to absorb exudates impart the PDEA with reliable wound healing. Altogether, this system demonstrates exceptional promise as an infection-mitigating, cell-stimulating, homeostasis-maintaining dressing for accelerated wound healing. The aim and objective of this study is to understand the mechanism of self-assembly in synthesized WLMs from PDEA and their application in wound healing.

Keywords: Block copolymers; hydrogel; self-assembly.