Food Protein-Based Nanodelivery Systems for Hydrophobic and Poorly Soluble Compounds

AAPS PharmSciTech. 2020 Mar 9;21(3):101. doi: 10.1208/s12249-020-01641-z.

Abstract

The hydrophobicity of bioactive molecules poses a considerable problem in the pharmaceutical and the food industry. Using food-based protein nanocarriers is one promising way to deliver hydrophobic molecules. These types of protein possess many functional properties such as surface activity, water-binding capacity, emulsification, foaming, gelation, and antioxidant activity, as well as their incorporation in the food industry as ingredients. Besides, they express low toxicity, are less expensive compared to synthetic polymers, and are biodegradable. This review aims to give a brief overview of the recent studies done using food proteins as colloidal delivery systems for hydrophobic and poorly soluble compounds.

Keywords: delivery system; food protein; hydrophobic; nanoparticles; poorly soluble compounds.

Publication types

  • Review

MeSH terms

  • Animals
  • Dietary Proteins / administration & dosage*
  • Dietary Proteins / chemistry*
  • Drug Delivery Systems / methods*
  • Drug Delivery Systems / trends
  • Gels
  • Humans
  • Hydrophobic and Hydrophilic Interactions / drug effects*
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry*
  • Polymers / administration & dosage
  • Polymers / chemistry
  • Solubility
  • Water

Substances

  • Dietary Proteins
  • Gels
  • Polymers
  • Water