Generation of human hepatocytes from extended pluripotent stem cells

Qiming Wang; Da Sun; Zhen Liang; Junyi Wang; Xinxing Zhong; Yulin Lyu; Junning Cao; Zhongqing Lin; Yuanyuan Du; Zhenchuan Miao; Shichun Lu; Cheng Li; Jun Xu; Yan Shi; Hongkui Deng

doi:10.1038/s41422-020-0293-x

Generation of human hepatocytes from extended pluripotent stem cells

Cell Res. 2020 Sep;30(9):810-813. doi: 10.1038/s41422-020-0293-x. Epub 2020 Mar 9.

Authors

Qiming Wang^#¹, Da Sun^#^{1

2}, Zhen Liang^#², Junyi Wang¹, Xinxing Zhong^{1

2}, Yulin Lyu³, Junning Cao⁴, Zhongqing Lin⁵, Yuanyuan Du^{1

6}, Zhenchuan Miao⁵, Shichun Lu⁴, Cheng Li³, Jun Xu⁷, Yan Shi⁸, Hongkui Deng^{9

10}

Affiliations

¹ School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China.
² State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology & Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China.
³ School of Life Sciences, Center for Bioinformatics, Center for Statistical Science, Peking University, 100871, Beijing, China.
⁴ Department of Hepatobiliary Surgery, The First Medical Center, Chinese PLA General Hospital, 28 Fuxing Road, Haidian, 100853, Beijing, China.
⁵ Beijing Vitalstar Biotechnology Co., Ltd, 100000, Beijing, China.
⁶ Hangzhou Repugene Technology Co., Ltd, Hangzhou, 311121, Zhejiang, China.
⁷ School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China. jun_xu@bjmu.edu.cn.
⁸ School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China. shiyan@bjmu.edu.cn.
⁹ School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center and the MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China. hongkui_deng@pku.edu.cn.
¹⁰ State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology & Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, Guangdong, China. hongkui_deng@pku.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation
Hepatocytes / cytology*
Human Embryonic Stem Cells / cytology
Human Embryonic Stem Cells / metabolism
Humans
Mice
Pluripotent Stem Cells / cytology*